Article

Cerebral blood flow in elastin haploinsufficient and 3xTg-AD mice

2025-08-22

Abstract excerpt

Artery structural properties and Alzheimer's disease (AD) pathology are individually associated with impaired cerebrovascular function; however, the interaction of these factors is unclear. Furthermore, while elastin haploinsufficient (Eln+/-) mice are known to have impaired cerebrovascular function, sex differences for this effect have not been previously studied. To answer these questions, we crossed middle-aged...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 469de1b0-4d75-5853-947c-da08aaf6f7cc
DOI: 10.1101/2025.08.18.670895

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cerebral blood flow in elastin haploinsufficient and 3xTg-AD miceDOI 10.1101/2025.08.18.670895Read

Assessment of Neurovascular Uncoupling: APOE Status is a Key Driver of Early Metabolic and Vascular DysfunctionSemantic proximity Read

Cell type-specific contributions to impaired blood-brain barrier and cerebral metabolism in presymptomatic 5XFAD miceSemantic proximity Read

Amyloid and Tau Pathology are Associated with Cerebral Blood Flow in a Mixed Sample of Nondemented Older Adults with and without Vascular Risk Factors for Alzheimer’s DiseaseSemantic proximity Read

APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease.Semantic proximity Read

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling.Semantic proximity Read

Smooth Muscle Dysfunction Drives Cerebrovascular Reserve Failure and End-Organ Brain InjurySemantic proximity Read

APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake miceSemantic proximity Read

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.Semantic proximity Read

<i>APOE4</i> genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in miceSemantic proximity Read

Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice.Semantic proximity Read

Microglia associations with brain pericytes and the vasculature are reduced in Alzheimer’s diseaseSemantic proximity Read

Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s diseaseSemantic proximity Read