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Article

APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease.

Neurobiology of disease - 1 Jun 2020

Lin Ai-Ling, Parikh Ishita, Yanckello Lucille M, White Renee S, Hartz Anika M S, Taylor Chase E, McCulloch Scott D, Thalman Scott W, Xia Mengfan, McCarty Katie, Ubele Margo, Head Elizabeth, Hyder Fahmeed, Sanganahalli Basavaraju G

Abstract excerpt

The ε4 allele of Apolipoprotein (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), the most common form of dementia. Cognitively normal APOE4 carriers have developed amyloid beta (Aβ) plaques and cerebrovascular, metabolic and structural deficits decades before showing the cognitive impairment. Interventions that can inhibit Aβ retention and restore the brain functions to normal would be...

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Identifiers

PMID: 32173556
DOI: 10.1016/j.nbd.2020.104834
PMCID: PMC7486698

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