Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer

Abstract excerpt

BACKGROUND: Analysis of cell-free DNA (cfDNA) is promising for broad applications in clinical settings, but with significant bias towards late-stage cancers. Although recent studies have discussed the diverse and degraded nature of cfDNA molecules, little is known about its impact on the practice of cfDNA analysis. METHODS: We developed single-strand library preparation and hybrid-capture-based cfDNA sequencing...

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