Article
Ultra-short cell-free DNA fragments enhance cancer early detection in a multi-analyte blood test combining mutation, protein and fragmentomics.
Clinical chemistry and laboratory medicine - 26 Jan 2024
Wang Fenfen, Li Xinxing, Li Mengxing, Liu Wendi, Lu Lingjia, Li Yang, Chen Xiaojing, Yang Siqi, Liu Tao, Cheng Wen, Weng Li, Wang Hongyan, Lu Dongsheng, Yao Qianqian, Wang Yingyu, Wu Johnny, Wittkop Tobias, Faham Malek, Zhou Huabang, Hu Heping, Jin Hai, Hu Zhiqian, Ma Ding, Cheng Xiaodong
Abstract excerpt
OBJECTIVES: Cancer morbidity and mortality can be reduced if the cancer is detected early. Cell-free DNA (cfDNA) fragmentomics emerged as a novel epigenetic biomarker for early cancer detection, however, it is still at its infancy and requires technical improvement. We sought to apply a single-strand DNA sequencing technology, for measuring genetic and fragmentomic features of cfDNA and evaluate the performance...
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