Article

Sequence determinants of intron-mediated enhancement learned from thousands of random introns

2024-10-29

Abstract excerpt

Spliceosomal introns are a ubiquitous feature of eukaryotic genes, whose presence often boosts the expression of their host gene, a phenomenon known as intron-mediated enhancement (IME). IME has been noted across diverse genes and organisms, but remains mysterious in many respects. For example, how does intron sequence affect the magnitude of IME? In this study, we performed a massively parallel reporter assay (MP...

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Literature Corpus work: 4693365c-8494-5a12-897a-f1feadfc6b94
DOI: 10.1101/2024.10.29.620880

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