Article

Tuberculosis susceptibility and vaccine protection are independently controlled by host genotype

2016-08-18

Abstract excerpt

The outcome of Mycobacterium tuberculosis (Mtb) infection and the immunological response to the Bacille Calmette Guerin (BCG) vaccine are highly variable in humans. Deciphering the relative importance of host genetics, environment, and vaccine preparation on BCG efficacy has proven difficult in natural populations. We developed a model system that captures the breadth of immunological responses observed in outbre...

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Literature Corpus work: 468aadc7-2479-52aa-8d6d-417e1292e9a4
DOI: 10.1101/064253

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