Article
The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection.
mSphere - 15 Apr 2020
Kurtz Sherry L, Rossi Amy P, Beamer Gillian L, Gatti Dan M, Kramnik Igor, Elkins Karen L
Abstract excerpt
Many studies of Mycobacterium tuberculosis infection and immunity have used mouse models. However, outcomes of vaccination and challenge with M. tuberculosis in inbred mouse strains do not reflect the full range of outcomes seen in people. Previous studies indicated that the novel Diversity Outbred (DO) mouse population exhibited a spectrum of outcomes after primary aerosol infection with M. tuberculosis Here, we...
Topics
- Animals
- Collaborative Cross Mice
- Disease Models, Animal
- Female
- Genetic Variation
- Male
- Mice
- Mice, Inbred C57BL
- Mycobacterium tuberculosis
- Tuberculosis
- Tuberculosis Vaccines
- Vaccination