Article
Host and pathogen genetic diversity shape vaccine-mediated protection to Mycobacterium tuberculosis.
Frontiers in immunology - 1 Jan 2024
Cohen Sara B, Plumlee Courtney R, Engels Lindsay, Mai Dat, Murray Tara A, Jahn Ana N, Alexander Bridget, Delahaye Jared L, Cross Lauren M, Maciag Karolina, Schrader Sam, Durga Kaitlin, Gold Elizabeth S, Aderem Alan, Gerner Michael Y, Gern Benjamin H, Diercks Alan H, Urdahl Kevin B
Abstract excerpt
To investigate how host and pathogen diversity govern immunity against Mycobacterium tuberculosis (Mtb), we performed a large-scale screen of vaccine-mediated protection against aerosol Mtb infection using three inbred mouse strains [C57BL/6 (B6), C3HeB/FeJ (C3H), Balb/c x 129/SvJ (C129F1)] and three Mtb strains (H37Rv, CDC1551, SA161) representing two lineages and distinct virulence properties. We compared three...
Topics
- Animals
- Mycobacterium tuberculosis
- Mice
- Genetic Variation
- Female
- Tuberculosis
- Tuberculosis Vaccines
- Mice, Inbred C57BL
- Mice, Inbred BALB C