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Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.

mBio - 20 Sept 2016

Smith Clare M, Proulx Megan K, Olive Andrew J, Laddy Dominick, Mishra Bibhuti B, Moss Caitlin, Gutierrez Nuria Martinez, Bellerose Michelle M, Barreira-Silva Palmira, Phuah Jia Yao, Baker Richard E, Behar Samuel M, Kornfeld Hardy, Evans Thomas G, Beamer Gillian, Sassetti Christopher M

Abstract excerpt

UNLABELLED: The outcome of Mycobacterium tuberculosis infection and the immunological response to the bacillus Calmette-Guerin (BCG) vaccine are highly variable in humans. Deciphering the relative importance of host genetics, environment, and vaccine preparation for the efficacy of BCG has proven difficult in natural populations. We developed a model system that captures the breadth of immunological responses...

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Identifiers

PMID: 27651361
DOI: 10.1128/mBio.01516-16
PMCID: PMC5030360

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Source receipt: pubmed, retrieved 7 Sept 2026.

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