Article

Fc₉₅, a next-generation Fc variant, achieves exceptional ADCC potency by linking affinity enhancement to intrinsic afucosylation

2026-06-15

Abstract excerpt

<title>Abstract</title> <p> Enhancing antibody-dependent cellular cytotoxicity (ADCC) is a central goal for immunotherapy, yet current strategies face a persistent engineering trade-off between potency, stability, and manufacturability. Here, we report Fc₉₅, an IgG1 Fc variant developed using Microenvironment-Tuned Interface Sculpting (MTIS), a design philosophy that systematically co-optimizes these competing p...

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Literature Corpus work: 4654cc41-8d95-563b-8275-06bbbadd8691
DOI: 10.21203/rs.3.rs-9897374/v1

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