Article
A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.
PLoS biology - 1 Jan 2016
de Jong Rob N, Beurskens Frank J, Verploegen Sandra, Strumane Kristin, van Kampen Muriel D, Voorhorst Marleen, Horstman Wendy, Engelberts Patrick J, Oostindie Simone C, Wang Guanbo, Heck Albert J R, Schuurman Janine, Parren Paul W H I
Abstract excerpt
IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into a novel technology platform (HexaBody technology) for therapeutic antibody potentiation. We identified mutations that enhanced hexamer formation and complement...
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