Article
Engineered antibody Fc variants with enhanced effector function.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2006
Lazar Greg A, Dang Wei, Karki Sher, Vafa Omid, Peng Judy S, Hyun Linus, Chan Cheryl, Chung Helen S, Eivazi Araz, Yoder Sean C, Vielmetter Jost, Carmichael David F, Hayes Robert J, Dahiyat Bassil I
Abstract excerpt
Antibody-dependent cell-mediated cytotoxicity, a key effector function for the clinical efficacy of monoclonal antibodies, is mediated primarily through a set of closely related Fcgamma receptors with both activating and inhibitory activities. By using computational design algorithms and high-throughput screening, we have engineered a series of Fc variants with optimized Fcgamma receptor affinity and specificity....
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