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Article

A variant human IgG1-Fc mediates improved ADCC.

Protein engineering, design & selection : PEDS - 1 Sept 2011

Stewart Ross, Thom George, Levens Michaela, Güler-Gane Gülin, Holgate Robert, Rudd Pauline M, Webster Carl, Jermutus Lutz, Lund John

Abstract excerpt

Ribosome display was applied to the Fc region of human immunoglobulin G (IgG1) to select for improved binding to human FcγRIIIa, the receptor expressed on human natural killer cells that mediates antibody-dependent cellular cytotoxicity (ADCC). A library of human Fcγ1 variants was generated using...

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Identifiers

PMID: 21596686
DOI: 10.1093/protein/gzr015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21596686-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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