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Article

Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies.

The Journal of biological chemistry - 7 Feb 2014

Liu Zhi, Gunasekaran Kannan, Wang Wei, Razinkov Vladimir, Sekirov Laura, Leng Esther, Sweet Heather, Foltz Ian, Howard Monique, Rousseau Anne-Marie, Kozlosky Carl, Fanslow William, Yan Wei

Abstract excerpt

Antibody-dependent cellular cytotoxicity (ADCC) is mediated through the engagement of the Fc segment of antibodies with Fcγ receptors (FcγRs) on immune cells upon binding of tumor or viral antigen. The co-crystal structure of FcγRIII in complex with Fc revealed that Fc binds to FcγRIII asymmetrically with two Fc chains contacting separate regions of the FcγRIII by utilizing different residues. To fully explore...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24311787
DOI: 10.1074/jbc.M113.513366
PMCID: PMC3916558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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