Article

APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress

2020-03-18

Abstract excerpt

Apolipoprotein L1 (APOL1) gene risk variants (RV) associate with renal and cardiovascular disease particularly in SLE. We hypothesized that in RV-carrying human umbilical vein endothelial cells (HUVECs) cytokine-induced APOL1 expression compromises mitochondrial respiration, lysosome integrity, and autophagic flux. HUVEC cultures of each APOL1 genotype were generated. APOL1 was expressed using IFNɣ; HUVEC mitochon...

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Literature Corpus work: 46400140-cc3b-5cb7-b324-1ceaf03b57d9
DOI: 10.1101/2020.03.18.996702

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