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APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress

27 Sept 2022

Abstract excerpt

Polymorphisms in the Apolipoprotein L1 ( APOL1 ) gene are common in ancestrally African populations, and associate with kidney injury and cardiovascular disease. These risk variants (RV) provide an advantage in resisting Trypanosoma brucei , the causal agent of African trypanosomiasis, and are largely absent from non-African genomes. Clinical associations between the APOL1 high risk genotype (HRG) and disease are...

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PMID: 36238153
DOI: 10.3389/fgene.2022.769936

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