Article
APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability.
American journal of physiology. Renal physiology - 1 Aug 2014
Lan Xiqian, Jhaveri Aakash, Cheng Kang, Wen Hongxiu, Saleem Moin A, Mathieson Peter W, Mikulak Joanna, Aviram Sharon, Malhotra Ashwani, Skorecki Karl, Singhal Pravin C
Abstract excerpt
Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To date, the cellular function and the role of APOL1 variants (Vs) in GS are still unknown. In this study, we examined the effects of overexpressing wild-type (G0) and kidney disease risk variants (G1 and G2) of APOL1 in human podocytes using a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.