Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOL1 Kidney Disease Risk Variants: An Evolving Landscape.

Seminars in nephrology - 1 May 2015

Dummer Patrick D, Limou Sophie, Rosenberg Avi Z, Heymann Jurgen, Nelson George, Winkler Cheryl A, Kopp Jeffrey B

Abstract excerpt

Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of chronic and end-stage kidney disease, which results in a significant global health disparity for persons of African ancestry. We estimate the lifetime risk of kidney disease in APOL1 dual-risk allele individuals to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lipoproteins, HDL
Share to Risk Factors
Share to Apolipoprotein L1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins

Share to APOL1 gene

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Kidney Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 26215860
DOI: 10.1016/j.semnephrol.2015.04.008
PMCID: PMC4562465

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26215860-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOL1 Kidney Disease Risk Variants: An Evolving Landscape.PMID 26215860Read ↗

Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.Semantic proximity Read ↗

ApoL1 Overexpression Drives Variant-Independent Cytotoxicity.Semantic proximity Read ↗

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore.Semantic proximity Read ↗

APOL1 and kidney cell functionSemantic proximity Read ↗

Apolipoprotein L1 and mechanisms of kidney disease susceptibility.Semantic proximity Read ↗

APOL1 toxin, innate immunity, and kidney injury.Semantic proximity Read ↗

Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicitySemantic proximity Read ↗

APOL1 and Kidney Disease: From Genetics to Biology.Semantic proximity Read ↗

A Cell Biologist’s View on APOL1: What We Know and What We Still Need to AddressSemantic proximity Read ↗

APOL1 polymorphisms and kidney disease: loss-of-function or gain-of-function?Semantic proximity Read ↗

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.Semantic proximity Read ↗

Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.