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Mitochondrial 3243A > G mutation confers pro-atherogenic and pro-inflammatory properties in MELAS iPS derived endothelial cells.

Cell death & disease - 22 Oct 2019

Pek Nicole Min Qian, Phua Qian Hua, Ho Beatrice Xuan, Pang Jeremy Kah Sheng, Hor Jin-Hui, An Omer, Yang Henry He, Yu Yang, Fan Yong, Ng Shi-Yan, Soh Boon-Seng

Abstract excerpt

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a mitochondrial disorder that is commonly caused by the m.3243A > G mutation in the MT-TL1 gene encoding for mitochondrial tRNA(Leu(UUR)). While clinical studies reported cerebral infarcts, atherosclerotic lesions, and altered vasculature and stroke-like episodes (SLE) in MELAS patients, it remains unclear how this...

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Identifiers

PMID: 31641105
DOI: 10.1038/s41419-019-2036-9
PMCID: PMC6805858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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