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Article

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion.

Journal of the American Society of Nephrology : JASN - 1 Nov 2017

Granado Daniel, Müller Daria, Krausel Vanessa, Kruzel-Davila Etty, Schuberth Christian, Eschborn Melanie, Wedlich-Söldner Roland, Skorecki Karl, Pavenstädt Hermann, Michgehl Ulf, Weide Thomas

Abstract excerpt

Population genetic approaches have uncovered a strong association between kidney diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and variant G2, compared with the nonrisk G0 allele. However, the mechanism whereby these variants lead to disease manifestation and, in particular, whether this involves an intracellular or extracellular pool of APOL1 remains unclear. Herein, we show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28696248
DOI: 10.1681/ASN.2016111220
PMCID: PMC5661279

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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