Article

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

2015-06-30

Abstract excerpt

Autocrine VEGF is necessary for endothelial survival, although the cellular mechanisms supporting this function are unknown. Here, we show that – even after full differentiation and maturation – continuous expression of VEGF by endothelial cells is needed to sustain vascular integrity and cellular viability. Depletion of VEGF from the endothelium results in mitochondria fragmentation and suppression ofglucosemetab...

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Literature Corpus work: 1fbbaa4b-667e-53b4-b463-e6132eee3783
DOI: 10.1242/dev.127480

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