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Article

ApoL1 Overexpression Drives Variant-Independent Cytotoxicity.

Journal of the American Society of Nephrology : JASN - 1 Mar 2018

O'Toole John F, Schilling William, Kunze Diana, Madhavan Sethu M, Konieczkowski Martha, Gu Yaping, Luo Liping, Wu Zhenzhen, Bruggeman Leslie A, Sedor John R

Abstract excerpt

Coding variants in the APOL1 gene are associated with kidney diseases in African ancestral populations; yet, the underlying biologic mechanisms remain uncertain. Variant-dependent autophagic and cytotoxic cell death have been proposed as pathogenic pathways mediating kidney injury. To examine this possibility, we conditionally expressed APOL1-G0 (reference), -G1, and -G2 (variants) using a tetracycline-regulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29180397
DOI: 10.1681/ASN.2016121322
PMCID: PMC5827587

Genes

APOL1

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