Shared etiology of Mendelian and complex disease supports drug discovery

Abstract excerpt

<title>Abstract</title> <p>Background Drugs targeting disease causal genes are more likely to succeed for that disease. However, complex disease causal genes are not always clear. In contrast, Mendelian disease causal genes are well-known and druggable. Here, we seek an approach to exploit the well characterized biology of Mendelian diseases for complex disease drug discovery, by exploiting evidence of pathogeni...

Topics

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• Comorbidity
• Disease
• Drug Discovery
• Genetic Diseases, Inborn
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Models, Genetic
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

3aac1a7b-294b-5924-a338-6b460a8c1b73

DOI

10.21203/rs.3.rs-4250176/v1