Shared etiology of Mendelian and complex disease supports drug discovery

Abstract excerpt

Drugs targeting disease causal genes are more likely to succeed for that disease. However, complex disease causal genes are not always clear. In contrast, Mendelian disease causal genes are well-known and druggable. Here, we seek an approach to exploit the well characterized biology of Mendelian diseases for complex disease drug discovery, by leveraging evidence of pathogenic processes shared between monogenic and...

Topics

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• Comorbidity
• Disease
• Drug Discovery
• Genetic Diseases, Inborn
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Models, Genetic
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

5e17665e-0b3f-5b3d-95f3-fa7be7f500f1

DOI

10.1101/2023.07.23.550190