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Article

Case-control studies of gene-environment interactions. When a case might not be the case.

PloS one - 1 Jan 2018

Lobach Iryna, Sampson Joshua, Alekseyenko Alexander, Lobach Siarhei, Zhang Li

Abstract excerpt

Case-control Genome-Wide Association Studies (GWAS) provide a rich resource for studying the genetic architecture of complex diseases. A key is to elucidate how the genetic effects vary by the environment, what is traditionally defined by Gene-Environment interactions (GxE). The overlooked complication is that multiple, distinct pathophysiologic mechanisms may lead to the same clinical diagnosis and often these...

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Identifiers

PMID: 30133451
DOI: 10.1371/journal.pone.0201140
PMCID: PMC6104951

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