Article

Challenges to case-only analysis for gene-environment interaction detection using polygenic risk scores: model assumptions and biases in large biobanks

2025-09-17

Abstract excerpt

Gene-environment interaction is important for studying complex diseases. Case-only analysis has been proposed to improve power for GxE detection. However, case-only analysis relies on key assumptions, including correct specification of the disease risk model and marginal independence between genetic and environmental variables. In this study, we systematically investigate the challenges of case-only analysis using...

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Literature Corpus work: 8b5d16c7-27d0-5031-8931-397731cbb967
DOI: 10.1101/2025.09.15.676316

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