Article
Pyramidal neurons proportionately alter cortical interneuron subtypes.
Nature - 1 Mar 2026
Wu Sherry Jingjing, Dai Min, Yang Shang-Po, McCann Cai, Qiu Yanjie, Kumar Vipin, Marrero Giovanni J, Tsyporin Jeremiah, Huang Shuhan, Shin David, Stogsdill Jeffrey A, Di Bella Daniela J, Xu Qing, Chen Bin, Farhi Samouil L, Macosko Evan Z, Chen Fei, Fishell Gord
Abstract excerpt
The mammalian cerebral cortex comprises a complex neuronal network that maintains a precise balance between excitatory pyramidal neurons and inhibitory interneurons. Accumulating evidence indicates that specific interneuron subtypes form stereotyped microcircuits with distinct pyramidal neuron classes1-3. Here we show that pyramidal neurons have an active role in this process by promoting the survival and...
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