Article

A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus

2025-11-06

Abstract excerpt

Autism is a highly heritable neurodevelopmental condition that manifests across a wide phenotypic spectrum. Rare and de novo loss-of-function mutations strongly predispose to autism and co-occurring developmental and intellectual disabilities in over 10% of autistic individuals. Understanding whether these variants converge on specific regional brain circuits or widely alter human brain development is crucial to...

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Literature Corpus work: a206cff2-8c4a-5a9f-8f3d-e9cac1eeb5c7
DOI: 10.1101/2025.11.05.685843

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