Article

Recurrent loss-of-function mutations reveal costs to OAS1 antiviral activity in primates

2018-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Immune responses counteract infections and can also cause collateral damage to hosts. We investigated functional outcomes of variation in the rapidly evolving antiviral double-stranded RNA (dsRNA) sensing factor Oligoadenylate Synthetase 1 (OAS1) in primates as a model for understanding how individual immune pathways evolve to minimize deleterious effects on host fitness. Upon binding of dsRNAs,...

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Literature Corpus work: 4604ffe7-7be7-54fa-a21b-d4a4a9df4ea6
DOI: 10.1101/326454

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