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Article

Control of Human Anelloviruses by Cytosine to Uracil Genome Editing

14 Nov 2022

Abstract excerpt

Despite significant attention on anellovirus research, the interaction between the anellovirus virome and the human host remains unknown. We show the dynamics of APOBEC3-mediated cytidine deaminase activity on anelloviruses during a 30-year period of chronic infection and postulate that this antiviral mechanism controls anelloviruses. These results expand our knowledge of anellovirus-host interactions, which may...

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PMID: 36374042
DOI: 10.1128/msphere.00506-22

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