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Article

Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.

Current topics in microbiology and immunology - 1 Jan 2008

Mashimo T, Simon-Chazottes D, Guénet J-L

Abstract excerpt

Mouse susceptibility to experimental infections with flaviviruses is significantly influenced by a cluster of genes on chromosome 5 encoding a family of proteins with enzymatic properties, the 2'-5' oligoadenylate synthetases (OAS). Positional cloning of the locus in question has revealed that susceptibility of laboratory inbred strains to this class of virus is associated with a nonsense mutation in the gene...

Topics

2',5'-Oligoadenylate Synthetase
Animals
Flavivirus Infections
Genetic Predisposition to Disease
Humans
Immunity, Innate
Mice

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18727488
DOI: 10.1007/978-3-540-75203-5_4
PMCID: PMC7122621

Genes

OAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.PMID 18727488Read ↗

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