Article

An Atypical RNA Quadruplex Marks RNAs as Vectors for Gene Silencing

2021-12-21

Abstract excerpt

The addition of poly(UG) ("pUG") repeats to 3' termini of mRNAs drives gene silencing and trans-generational epigenetic inheritance in the metazoan C. elegans. pUG tails promote silencing by recruiting an RNA-dependent RNA Polymerase (RdRP) that synthesizes small interfering (si)RNAs. Here we show that active pUG tails require a minimum of 11.5 repeats and adopt a quadruplex (G4)2 structure we term the pUG fold. T...

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Literature Corpus work: 45fe0c15-d202-5988-98d1-9a130753911f
DOI: 10.1101/2021.12.21.472683

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