Article

The structure, folding kinetics and dynamics of long poly(UG) RNA

2025-04-23

Abstract excerpt

Long poly(UG) or “pUG” dinucleotide repeats are abundant in eukaryotic transcriptomes. Thousands of human genes have pUGs longer than 24 repeats, including the cancer-associated lncRNA NEAT1. In C. elegans , enzymatic addition of long pUGs to RNA 3′ ends (pUG tails) marks RNAs as vectors of gene silencing. Gene silencing requires at least one pUG fold, a left-handed quadruplex structure that incorporates 12 repea...

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Literature Corpus work: 2103e7a4-4334-5b6d-9daa-e4af9673ed47
DOI: 10.1101/2025.04.22.650042

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