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The structure, folding kinetics, and dynamics of long poly(UG) RNA

19 Jul 2025

Abstract excerpt

Long poly(UG) or "pUG" dinucleotide repeats are abundant in eukaryotic transcriptomes. Over a thousand human genes have pUGs longer than 24 repeats, including the cancer-associated lncRNA NEAT1. In C. elegans, enzymatic addition of long pUGs to RNA 3' ends (pUG tails) marks RNAs as vectors of gene silencing. Gene silencing requires at least one pUG fold, a left-handed quadruplex structure that incorporates 12...

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PMID: 40682817
DOI: 10.1093/nar/gkaf685

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