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Poly(UG)-tailed RNAs are involved in the control of thousands of genes predominantly in the germline in <i>Pristionchus pacificus</i>

2025-09-01

Abstract excerpt

In the nematode Caenorhabditis elegans , the terminal transferase RDE-3 adds a poly(UG)-tail to the free 3’ end of RNA molecules generated by the action of primary siRNAs or piRNAs. The tailed RNA serves as a template for RNA-dependent RNA polymerases (RdRp) to generate secondary siRNAs, thereby reinforcing the RNAi effect. In this iterative process, progressively shorter tailed RNAs are formed. In C. elegans ,...

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Identifiers and source

Literature Corpus work
2f72190d-74c7-586b-985b-360fb39f46ee
DOI
10.1101/2025.09.01.673539
Open publication

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Poly(UG)-tailed RNAs are involved in the control of thousands of genes predominantly in the germline in <i>Pristionchus pacificus</i>DOI 10.1101/2025.09.01.673539
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