Article
Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease.
Nature communications - 23 Nov 2022
Fernández Zapata Camila, Giacomello Ginevra, Spruth Eike J, Middeldorp Jinte, Gallaccio Gerardina, Dehlinger Adeline, Dames Claudia, Leman Julia K H, van Dijk Roland E, Meisel Andreas, Schlickeiser Stephan, Kunkel Desiree, Hol Elly M, Paul Friedemann, Parr Maria Kristina, Priller Josef, Böttcher Chotima
Abstract excerpt
Myeloid cells are suggested as an important player in Alzheimer´s disease (AD). However, its continuum of phenotypic and functional changes across different body compartments and their use as a biomarker in AD remains elusive. Here, we perform multiple state-of-the-art analyses to phenotypically and metabolically characterize immune cells between peripheral blood (n = 117), cerebrospinal fluid (CSF, n = 117),...
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