Article

Hippocampal Glucuronyl C5-epimerase promotes stress resilience by directly engaging PI3K through a non-enzymatic mechanism

2026-05-06

Abstract excerpt

Major depressive disorder (MDD) seriously affects human physical and mental health and causes global socioeconomic burdens. Stress-induced depressive etiology is linked to dendritic atrophy in the hippocampus, however, the underlying mechanism was poorly understood. Here, we identify that glucuronyl C5-epimerase ( Glce ), a heparan sulfae-modifying enzyme, as a critical regulator of hippocampal dendritic integrit...

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Literature Corpus work: 45c14bd5-2e86-5d1b-bda0-e425fdeaf7b9
DOI: 10.64898/2026.05.02.722405

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