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Article

Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex.

Scientific reports - 24 Apr 2020

Cho Yoonjeong, Hwang Hongik, Rahman Md Ataur, Chung ChiHye, Rhim Hyewhon

Abstract excerpt

Depression is a devastating mental disorder affected by multiple factors that can have genetic, environmental, or metabolic causes. Although previous studies have reported an association of dysregulated glucose metabolism with depression, its underlying mechanism remains elusive at the molecular level. A small percentage of glucose is converted into uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) via the...

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Identifiers

PMID: 32332789
DOI: 10.1038/s41598-020-63819-6
PMCID: PMC7181662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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