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Article

Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.

Advances in experimental medicine and biology - 1 Jan 2026

Lee Kang Joon, Kim Yong-Ku

Abstract excerpt

Late-life depression (LLD) is a prevalent and debilitating disease closely associated with cognitive decline, exacerbation of chronic medical illness, decreased quality of life, and increased societal burden. This review explores the complex neurobiological mechanisms and key risk factors underlying LLD. Inflammation, particularly involving cytokines such as IL-6 and TNF-α and the activation of the NLRP3...

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Identifiers

PMID: 42036573
DOI: 10.1007/978-981-95-6872-7_16

Genes

BDNF
MTHFR
NLRP3
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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