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Deep Lipidomic Phenotyping Identifies Ceramide-Centered Lipotoxicity and Depletion of Plasmalogen-Carnitine Pathways in Major Depressive Disorder: Implications for Precision Medicine

2026-02-04

Abstract excerpt

<h4>Background</h4> Major depressive disorder (MDD) severely impairs individual health and creates heavy societal burdens. Diagnostic and therapeutic research remains hindered by MDD’s marked heterogeneity and the absence of valid biomarkers. As a neuro-immune, metabolic, and oxidative stress (NIMETOX) disorder, MDD exhibits metabolomic signatures as a final common pathway in the Chinese population. <h4>Objective...

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Literature Corpus work: 8ec96dee-b096-59ba-b16a-c2ebb5e4d41a
DOI: 10.64898/2026.02.01.26345328

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