Article

Intron Retention as a Homeostatic State Variable for Drug Response and Recovery: Lessons from Depression for Broader Applications

2026-02-27

Abstract excerpt

Clinically robust molecular biomarkers for depression have remained elusive, despite extensive transcriptomic research. This gap is consequential: depression is prevalent and heterogeneous, yet objective measures to quantify burden, stratify patients, and track recovery remain limited. Here we review evidence that intron retention (IR) can serve as a homeostatic state variable—and therefore a sensitive biomarker—r...

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Literature Corpus work: 02c276fb-04b6-5f23-bd00-ddd91324d3c6
DOI: 10.20944/preprints202602.1820.v1

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