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Article

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta.

Nature structural & molecular biology - 1 Sept 2009

Swan Michael K, Johnson Robert E, Prakash Louise, Prakash Satya, Aggarwal Aneel K

Abstract excerpt

DNA polymerase delta (Pol delta) is a high-fidelity polymerase that has a central role in replication from yeast to humans. We present the crystal structure of the catalytic subunit of yeast Pol delta in ternary complex with a template primer and an incoming nucleotide. The structure, determined at 2.0-A resolution, catches the enzyme in the act of replication, revealing how the polymerase and exonuclease domains...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19718023
DOI: 10.1038/nsmb.1663
PMCID: PMC3055789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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