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PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass

24 Oct 2023

Abstract excerpt

The primase/polymerase PRIMPOL restarts DNA synthesis when replication is arrested by template impediments. However, we do not have a comprehensive view of how PRIMPOL-dependent repriming integrates with the main pathways of damage tolerance, REV1-dependent 'on-the-fly' lesion bypass at the fork and PCNA ubiquitination-dependent post-replicative gap filling. Guided by genome-wide CRISPR/Cas9 screens to survey the...

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PMID: 37971291
DOI: 10.1093/nar/gkad1054

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