Article

Histone demethylation and c-MYC activation enhance translational capacity in response to amino acid restriction

2017-06-23

Abstract excerpt

Nutrient limitation may elicit adaptive epigenetic changes but the nature and mechanisms of the cellular response to specific nutrient deficiencies are incompletely understood. We report that depriving human cells of amino acids (AAs) induces specific loss of H4K20me1 from gene bodies and elevated binding of c-MYC at promoters genome-wide. These effects are most pronounced at ribosomal protein and translation init...

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Literature Corpus work: 45ac0fdd-29c6-5a92-9d97-51e4b0d762bb
DOI: 10.1101/154419

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