Article

Methionine Metabolism Controls the B-cell EBV Epigenome and Viral Latency

2022-02-24

Abstract excerpt

<h4>Summary</h4> Epstein-Barr virus (EBV) subverts host epigenetic pathways to switch between viral latency programs, colonize the B-cell compartment and reactivate. Within memory B-cells, the reservoir for lifelong infection, EBV genomic DNA and histone methylation marks restrict gene expression. But, this epigenetic strategy also enables EBV-infected tumors, including Burkitt lymphomas to evade immune detection...

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Literature Corpus work: 1972de7e-6024-52bb-88e7-2c6671a214a6
DOI: 10.1101/2022.02.24.481783

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