Article

Extracellular protein catabolism drives regulated nitrogen handling and ammonia buffering in acute myeloid leukemia

2026-08-28

Abstract excerpt

Acute myeloid leukemia (AML) cells exhibit pronounced metabolic plasticity, yet how amino acid supply is coordinated to sustain leukemic metabolism remains poorly understood. Here, we show that AML cells catabolize extracellular proteins as a major source of amino acids through lysosomal degradation of albumin. This proteocatabolic activity supports anabolic processes and mitochondrial energy production and establ...

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Literature Corpus work: 345a2439-1983-531c-96ea-21539867b377
DOI: 10.64898/2026.08.27.747222

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