Article

ISGylation of STING contributes to neuroinflammation and neurodegeneration via activating c-Fos in Parkinson's disease models

2026-06-25

Abstract excerpt

<title>Abstract</title> <p> Type-I interferons (IFNs), as key mediators of innate immune response, have been implicated in neurodegenerative diseases, including Parkinson’s disease (PD). IFN exerts various biological effects by activating hundreds of interferon-stimulated genes (ISGs), including ISG15. ISG15 mediate ISGylation by covalently linking modifying target proteins including STING. The present study aim...

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Literature Corpus work: 4594f5c8-e20e-5934-8a4c-f40db28bdc87
DOI: 10.21203/rs.3.rs-10118411/v1

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