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Article

STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infection

21 Jun 2025

Abstract excerpt

BACKGROUND: Stimulator of interferon (IFN) genes (STING) is a central adaptor protein in the cGAS-STING signaling pathway, orchestrating the production of type I interferons (IFNs) in response to cytosolic DNA detection, a crucial mechanism in antiviral defense. However, further investigation is needed to understand how post-transcriptional regulation, particularly alternative splicing, modulates STING activity....

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PMID: 40544261
DOI: 10.1186/s12964-025-02305-w

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