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Article

Mechanistic characterization of <i>RASGRP1</i> variants identifies an hnRNP K-regulated transcriptional enhancer contributing to SLE susceptibility

2019-03-06

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component. We recently identified a novel SLE susceptibility locus near RASGRP1 , which governs the ERK/MAPK kinase cascade and B-/T-cell differentiation and development. However, precise causal RASGRP1 functional variant(s) and their mechanisms of action in SLE pathogenesis remain undefined. Our goal was to fine-map this locus, pr...

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Identifiers and source

Literature Corpus work
45718bc4-ac35-522d-a9e3-77dece47b920
DOI
10.1101/568790
Open publication

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Mechanistic characterization of <i>RASGRP1</i> variants identifies an hnRNP K-regulated transcriptional enhancer contributing to SLE susceptibilityDOI 10.1101/568790
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