Article

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

2019-06-06

Abstract excerpt

RasGRP1 is a Ras guanine nucleotide exchange factor, and an essential regulator of lymphocyte receptor signaling. In mice, Rasgrp1 deletion results in defective T lymphocyte development. RASGRP1 -deficient patients suffer from immune deficiency, and the RASGRP1 gene has been linked to autoimmunity. However, how RasGRP1 levels are regulated, and if RasGRP1 dosage alterations contribute to autoimmunity remains un...

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Literature Corpus work: edf22873-8fa4-570c-99b4-4a703634b3d7
DOI: 10.1101/656454

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